The role of DNA dependent protein kinase in synapsis of DNA ends

DNA dependent protein kinase (DNA-PK) plays a central role in the non-homologous end-joining pathway of DNA double strand break repair. Its catalytic subunit (DNA-PK(CS)) functions as a serine/threonine protein kinase. We show that DNA-PK forms a stable complex at DNA termini that blocks the action...

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Bibliographic Details

Published in:	Nucleic Acids Res
Main Authors:	Weterings, Eric, Verkaik, Nicole S., Brüggenwirth, Hennie T., Hoeijmakers, Jan H. J., van Gent, Dik C.
Format:	Artigo
Language:	Inglês
Published:	Oxford University Press 2003
Subjects:	Articles
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC291856/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14654699/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg889
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