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Large T antigen on the simian virus 40 origin of replication: a 3D snapshot prior to DNA replication
Large T antigen is the replicative helicase of simian virus 40. Its specific binding to the origin of replication and oligomerization into a double hexamer distorts and unwinds dsDNA. In viral replication, T antigen acts as a functional homolog of the eukaryotic minichromosome maintenance factor MCM...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC291853/ https://ncbi.nlm.nih.gov/pubmed/14633980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg612 |
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