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Glucosylceramide synthesis inhibition affects cell cycle progression, membrane trafficking, and stage differentiation in Giardia lamblia

Synthesis of glucosylceramide via glucosylceramide synthase (GCS) is a crucial event in higher eukaryotes, both for the production of complex glycosphingolipids and for regulating cellular levels of ceramide, a potent antiproliferative second messenger. In this study, we explored the dependence of t...

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Detalhes bibliográficos
Main Authors: Štefanić, Saša, Spycher, Cornelia, Morf, Laura, Fabriàs, Gemma, Casas, Josefina, Schraner, Elisabeth, Wild, Peter, Hehl, Adrian B., Sonda, Sabrina
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918437/
https://ncbi.nlm.nih.gov/pubmed/20335568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M003392
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