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High endoplasmic reticulum activity renders multiple myeloma cells hypersensitive to mitochondrial inhibitors
Multiple myeloma (MM) cells continuously secrete large amounts of immunoglobulins that are folded in the endoplasmic reticulum (ER) whose function depend on the Ca(2+) concentration inside its lumen. Recently, it was shown that the ER membrane leaks Ca(2+) that is captured and delivered back by mito...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2918425/ https://ncbi.nlm.nih.gov/pubmed/19779717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-009-1143-1 |
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