Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma

BACKGROUND: Previously, we found that mast cell tryptases and carboxypeptidase A3 (CPA3) are differentially expressed in the airway epithelium in asthmatic subjects. We also found that asthmatic subjects can be divided into 2 subgroups (“T(H)2 high” and “T(H)2 low” asthma) based on epithelial cell g...

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Main Authors: Dougherty, Ryan H., Sidhu, Sukhvinder S., Raman, Kavita, Solon, Margaret, Solberg, Owen D., Caughey, George H., Woodruff, Prescott G., Fahy, John V.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918406/
https://ncbi.nlm.nih.gov/pubmed/20451039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2010.03.003
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