Ex Vivo Sputum Analysis Reveals Impairment of Protease-dependent Mucus Degradation by Plasma Proteins in Acute Asthma

Rationale: Airway mucus plugs, composed of mucin glycoproteins mixed with plasma proteins, are an important cause of airway obstruction in acute severe asthma, and they are poorly treated with current therapies. Objectives: To investigate mechanisms of airway mucus clearance in health and in acute s...

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Bibliografski detalji
Glavni autori: Innes, Anh L., Carrington, Stephen D., Thornton, David J., Kirkham, Sara, Rousseau, Karine, Dougherty, Ryan H., Raymond, Wilfred W., Caughey, George H., Muller, Susan J., Fahy, John V.
Format: Artigo
Jezik:Inglês
Izdano: American Thoracic Society 2009
Teme:
A. Asthma and Allergy
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724713/
https://ncbi.nlm.nih.gov/pubmed/19423716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200807-1056OC
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