Systemic autoimmunity and defective Fas ligand secretion in the absence of the Wiskott-Aldrich syndrome protein

Autoimmunity is a surprisingly common complication of primary immunodeficiencies, yet the molecular mechanisms underlying this clinical observation are not well understood. One widely known example is provided by Wiskott-Aldrich syndrome (WAS), an X-linked primary immunodeficiency disorder caused by...

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Autores principales: Nikolov, Nikolay P., Shimizu, Masaki, Cleland, Sophia, Bailey, Daniel, Aoki, Joseph, Strom, Ted, Schwartzberg, Pamela L., Candotti, Fabio, Siegel, Richard M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2010
Materias:
Immunobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918330/
https://ncbi.nlm.nih.gov/pubmed/20457871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-237560
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