Regulation of myeloid leukemia by the cell fate determinant Musashi

Chronic myelogenous leukemia (CML) can progress from an indolent chronic phase to an aggressive blast crisis phase1 but the molecular basis of this transition remains poorly understood. Here we have used mouse models of CML2,3 to show that disease progression is regulated by the Musashi-Numb signali...

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Detalhes bibliográficos
Main Authors: Ito, Takahiro, Kwon, Hyog Young, Zimdahl, Bryan, Congdon, Kendra L., Blum, Jordan, Lento, William E., Zhao, Chen, Lagoo, Anand, Gerrard, Gareth, Foroni, Letizia, Goldman, John, Goh, Harriet, Kim, Soo-Hyun, Kim, Dong-Wook, Chuah, Charles, Oehler, Vivian G., Radich, Jerald P., Jordan, Craig T., Reya, Tannishtha
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918284/
https://ncbi.nlm.nih.gov/pubmed/20639863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09171
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