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Solid-Phase Synthesis of N-Substituted Pyrrolidinone Tethered N-substituted Piperidines via Ugi Reaction

Starting with resin-bound glutamic acid, an efficient synthesis of N-substituted pyrrolidinones is described utilizing the Ugi four-component reaction (U-4CR). The same methodology is employed to produce N-substituted pyrrolidinone tethered N-substituted piperidines.

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Detalhes bibliográficos
Main Authors: Liu, Zhang, Nefzi, Adel
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917892/
https://ncbi.nlm.nih.gov/pubmed/20527770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cc100054u
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