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Solid-Phase Synthesis of N-Substituted Pyrrolidinone Tethered N-substituted Piperidines via Ugi Reaction
Starting with resin-bound glutamic acid, an efficient synthesis of N-substituted pyrrolidinones is described utilizing the Ugi four-component reaction (U-4CR). The same methodology is employed to produce N-substituted pyrrolidinone tethered N-substituted piperidines.
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2917892/ https://ncbi.nlm.nih.gov/pubmed/20527770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cc100054u |
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