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Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells

Macropinocytosis is regulated by Abl kinase via an unknown mechanism. We previously demonstrated that Abl kinase activity is, itself, regulated by Abi1 subsequent to Abl kinase phosphorylation of Abi1 tyrosine 213 (pY213) [1]. Here we show that blocking phosphorylation of Y213 abrogated the ability...

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Bibliographische Detailangaben
Hauptverfasser: Dubielecka, Patrycja M., Machida, Kazuya, Xiong, Xiaoling, Hossain, Sajjad, Ogiue-Ikeda, Mari, Carrera, Ana C., Mayer, Bruce J., Kotula, Leszek
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917628/
https://ncbi.nlm.nih.gov/pubmed/20598684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.06.029
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