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Metronomic Dosing Enhances the Antiangiogenic Effect of Epothilone B
BACKGROUND: High doses (10nM) of epothilone B, a microtubule stabilizer, will inhibit the development of human tumor-derived angiogenesis following short (14 day) drug exposure times. Metronomic dosing regimes use lower drug doses and prolonged drug exposure times in an attempt to decrease toxicity...
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| Glavni autori: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2917534/ https://ncbi.nlm.nih.gov/pubmed/20338584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2009.12.001 |
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