Small Molecule GS-Nitroxide Ameliorates Ionizing Irradiation-Induced Delay in Bone Wound Healing in a Novel Murine Model

We studied radioprotection and mitigation by mitochondrial-targeted Tempol (GS-nitroxide, JP4-039), in a mouse injury/irradiation model of combined injury (fracture/irradiation). Right hind legs of control C57BL/6NHsd female mice, mice pretreated with MnSOD-PL, JP4-039, or with amifostine were irrad...

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Bibliographic Details
Main Authors: Gokhale, Abhay, Rwigema, Jean-Claude, Epperly, Michael, Glowacki, Julie, Wang, Hong, Wipf, Peter, Goff, Julie P., Dixon, Tracy, Patrene, Ken, Greenberger, Joel S.
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916688/
https://ncbi.nlm.nih.gov/pubmed/20668303
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