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Inhibition of HIV Fusion with Multivalent Gold Nanoparticles
The design and synthesis of a multivalent gold nanoparticle therapeutic is presented. SDC-1721, a fragment of the potent HIV inhibitor TAK-779, was synthesized and conjugated to 2.0 nm diameter gold nanoparticles. Free SDC-1721 had no inhibitory effect on HIV infection; however, the (SDC-1721)-gold...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2916654/ https://ncbi.nlm.nih.gov/pubmed/18473457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja710321g |
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