Identification of the Biosynthetic Gene Cluster for the Pseudomonas aeruginosa Antimetabolite l-2-Amino-4-Methoxy-trans-3-Butenoic Acid

l-2-Amino-4-methoxy-trans-3-butenoic acid (AMB) is a potent antibiotic and toxin produced by Pseudomonas aeruginosa. Using a novel biochemical assay combined with site-directed mutagenesis in strain PAO1, we have identified a five-gene cluster specifying AMB biosynthesis, probably involving a thiote...

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Bibliographische Detailangaben
Hauptverfasser: Lee, Xiaoyun, Fox, Áine, Sufrin, Janice, Henry, Hugues, Majcherczyk, Paul, Haas, Dieter, Reimmann, Cornelia
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
Schlagworte:
Physiology and Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916419/
https://ncbi.nlm.nih.gov/pubmed/20543073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00492-10
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