Sphingosine Kinase 1 Induces Tolerance to Human Epidermal Growth Factor Receptor 2 and Prevents Formation of a Migratory Phenotype in Response to Sphingosine 1-Phosphate in Estrogen Receptor-Positive Breast Cancer Cells

We demonstrate here a new concept termed “oncogene tolerance” whereby human EGF receptor 2 (HER2) increases sphingosine kinase 1 (SK1) expression in estrogen receptor-positive (ER(+)) MCF-7 HER2 cells and SK1, in turn, limits HER2 expression in a negative-feedback manner. The HER2-dependent increase...

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Hauptverfasser: Long, Jaclyn S., Edwards, Joanne, Watson, Carol, Tovey, Sian, Mair, Kirsty M., Schiff, Rachel, Natarajan, Viswanathan, Pyne, Nigel J., Pyne, Susan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916408/
https://ncbi.nlm.nih.gov/pubmed/20516217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01133-09
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