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Drosophila von Hippel-Lindau Tumor Suppressor Gene Function in Epithelial Tubule Morphogenesis

Mutations in the human von Hippel-Lindau (VHL) gene are the cause of VHL disease that displays multiple benign and malignant tumors. The VHL gene has been shown to regulate angiogenic potential and glycolic metabolism via its E3 ubiquitin ligase function against the alpha subunit of hypoxia-inducibl...

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Bibliographic Details
Main Authors: Hsouna, Anita, Nallamothu, Gouthami, Kose, Nurgun, Guinea, Maria, Dammai, Vincent, Hsu, Tien
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916397/
https://ncbi.nlm.nih.gov/pubmed/20516215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01578-09
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