Cell Wall Thickening Is Not a Universal Accompaniment of the Daptomycin Nonsusceptibility Phenotype in Staphylococcus aureus: Evidence for Multiple Resistance Mechanisms

The mechanism(s) of daptomycin (DAP) resistance (DAP(r)) is incompletely defined. Thickened cell walls (CWs) acting as either a mechanical barrier or an affinity trap for DAP have been purported to be a major contributor to the DAP(r) phenotype. To this end, we studied an isogenic set of methicillin...

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Autors principals: Yang, Soo-Jin, Nast, Cynthia C., Mishra, Nagendra N., Yeaman, Michael R., Fey, Paul D., Bayer, Arnold S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916340/
https://ncbi.nlm.nih.gov/pubmed/20498310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00122-10
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