Mutational Analysis of VIM-2 Reveals an Essential Determinant for Metallo-β-Lactamase Stability and Folding

Metallo-β-lactamase (MBL)-producing bacteria are emerging worldwide and represent a formidable threat to the efficacy of relevant β-lactams, including carbapenems, expanded-spectrum cephalosporins, and β-lactamase inactivator/β-lactam combinations. VIM-2 is currently the most widespread MBL and repr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Borgianni, Luisa, Vandenameele, Julie, Matagne, André, Bini, Luca, Bonomo, Robert A., Frère, Jean-Marie, Rossolini, Gian Maria, Docquier, Jean-Denis
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2010
Pynciau:
Mechanisms of Resistance
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916320/
https://ncbi.nlm.nih.gov/pubmed/20498317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01336-09
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