The histone deacetylase inhibitor valproic acid sensitizes human and canine osteosarcoma to doxorubicin

PURPOSE: Osteosarcoma (OS) remains an incurable and ultimately fatal disease in many patients, and novel forms of therapy are needed. Improved models of OS that more closely mimic human disease would provide more robust information regarding the utility of novel therapies. Spontaneous OS in dogs may...

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Bibliographic Details
Main Authors: Wittenburg, Luke A., Bisson, Liam, Rose, Barbara J., Korch, Christopher, Thamm, Douglas H.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916050/
https://ncbi.nlm.nih.gov/pubmed/20306194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-010-1287-z
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