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A Transient Kinetic Approach to Investigate Nucleoside Inhibitors of Mitochondrial DNA polymerase γ
Nucleoside analogs play an essential role in treating human immunodeficiency virus (HIV) infection since the beginning of the AIDS epidemic and work by inhibition of HIV-1 reverse transcriptase (RT), a viral polymerase essential for DNA replication. Today, over 90% of all regimens for HIV treatment...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2916041/ https://ncbi.nlm.nih.gov/pubmed/20573564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2010.05.001 |
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