Subdomain 3 of Plasmodium falciparum VAR2CSA DBL3x Is Identified as a Minimal Chondroitin Sulfate A-binding Region

Molecular interactions between the VAR2CSA protein, expressed on the surface of Plasmodium falciparum-infected erythrocytes, and placental chondroitin sulfate A (CSA) are primarily responsible for pregnancy-associated malaria (PAM). Interrupting these interactions may prevent or ameliorate the sever...

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Autores principales: Singh, Kavita, Gitti, Rossitza K., Diouf, Ababacar, Zhou, Hong, Gowda, D. Channe, Miura, Kazutoyo, Ostazeski, Stanley A., Fairhurst, Rick M., Garboczi, David N., Long, Carole A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915721/
https://ncbi.nlm.nih.gov/pubmed/20529864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.118612
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