Serpins Flex Their Muscle: II. STRUCTURAL INSIGHTS INTO TARGET PEPTIDASE RECOGNITION, POLYMERIZATION, AND TRANSPORT FUNCTIONS

Inhibitory serpins are metastable proteins that undergo a substantial conformational rearrangement to covalently trap target peptidases. The serpin reactive center loop contributes a majority of the interactions that serpins make during the initial binding to target peptidases. However, structural s...

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Hauptverfasser: Whisstock, James C., Silverman, Gary A., Bird, Phillip I., Bottomley, Stephen P., Kaiserman, Dion, Luke, Cliff J., Pak, Stephen C., Reichhart, Jean-Marc, Huntington, James A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915666/
https://ncbi.nlm.nih.gov/pubmed/20498368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R110.141408
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