Serpins Flex Their Muscle: I. PUTTING THE CLAMPS ON PROTEOLYSIS IN DIVERSE BIOLOGICAL SYSTEMS

Serpins compose the largest superfamily of peptidase inhibitors and are well known as regulators of hemostasis and thrombolysis. Studies using model organisms, from plants to vertebrates, now show that serpins and their unique inhibitory mechanism and conformational flexibility are exploited to cont...

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Autores principales: Silverman, Gary A., Whisstock, James C., Bottomley, Stephen P., Huntington, James A., Kaiserman, Dion, Luke, Cliff J., Pak, Stephen C., Reichhart, Jean-Marc, Bird, Phillip I.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915665/
https://ncbi.nlm.nih.gov/pubmed/20498369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R110.112771
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