Serpins Flex Their Muscle: I. PUTTING THE CLAMPS ON PROTEOLYSIS IN DIVERSE BIOLOGICAL SYSTEMS

Serpins compose the largest superfamily of peptidase inhibitors and are well known as regulators of hemostasis and thrombolysis. Studies using model organisms, from plants to vertebrates, now show that serpins and their unique inhibitory mechanism and conformational flexibility are exploited to cont...

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Bibliografiske detaljer
Main Authors: Silverman, Gary A., Whisstock, James C., Bottomley, Stephen P., Huntington, James A., Kaiserman, Dion, Luke, Cliff J., Pak, Stephen C., Reichhart, Jean-Marc, Bird, Phillip I.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915665/
https://ncbi.nlm.nih.gov/pubmed/20498369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R110.112771
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