Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans

BACKGROUND: The gene daf-2 encodes the single insulin/insulin growth factor-1-like receptor of Caenorhabditis elegans. The reduction-of-function allele e1370 induces several metabolic alterations and doubles lifespan. RESULTS: We found that the e1370 mutation alters aerobic energy production substan...

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Autors principals: Brys, Kristel, Castelein, Natascha, Matthijssens, Filip, Vanfleteren, Jacques R, Braeckman, Bart P
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914644/
https://ncbi.nlm.nih.gov/pubmed/20584279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-8-91
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