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Altered levels and distribution of APP and its processing enzymes in Niemann-Pick Type C1-deficient mouse brains

Niemann-Pick type C (NPC) disease is an autosomal recessive neurodegenerative disorder characterized by intracellular accumulation of cholesterol and glycosphingolipids in many tissues including the brain. The disease is caused by mutations of either NPC1 or NPC2 gene and is accompanied by a severe...

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Detalhes bibliográficos
Main Authors: Kodam, A., Maulik, M., Peake, K., Amritraj, A., Vetrivel, K.S., Thinakaran, G., Vance, J.E., Kar, S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914615/
https://ncbi.nlm.nih.gov/pubmed/20607864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.21001
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