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The Role of Genetic Variation Near Interferon-Kappa in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by increased type I interferons (IFNs) and multiorgan inflammation frequently targeting the skin. IFN-kappa is a type I IFN expressed in skin. A pooled genome-wide scan implicated the IFNK locus in SLE susceptibility....

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Main Authors: Harley, Isaac T. W., Niewold, Timothy B., Stormont, Rebecca M., Kaufman, Kenneth M., Glenn, Stuart B., Franek, Beverly S., Kelly, Jennifer A., Kilpatrick, Jeffrey R., Hutchings, David, Divers, Jasmin, Bruner, Gail R., Edberg, Jeffrey C., McGwin, Gerald, Petri, Michelle A., Ramsey-Goldman, Rosalind, Reveille, John D., Vilá-Pérez, Luis M., Merrill, Joan T., Gilkeson, Gary S., Vyse, Timothy J., Alarcón-Riquelme, Marta E., Cho, Soo-Kyung, Jacob, Chaim O., Alarcón, Graciela S., Moser, Kathy L., Gaffney, Patrick M., Kimberly, Robert P., Bae, Sang-Cheol, Langefeld, Carl D., Harley, John B., Guthridge, Joel M., James, Judith A.
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914299/
https://ncbi.nlm.nih.gov/pubmed/20706608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/706825
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