Role of SV40 Integration Site at Chromosomal Interval 1q21.1 in Immortalized CRL2504 Cells

We have applied a functional gene transfer strategy to demonstrate the importance of viral integration site in cellular immortalization. The large tumor antigen of SV40 is capable of extending the cellular life span by sequestering tumor suppressor proteins pRB and p53 in virus-transformed human cel...

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Bibliografiske detaljer
Main Authors: Liu, Jinglan, Kaur, Gurpreet, Zhawar, Vikramjit K., Zimonjic, Drazen B., Popescu, Nicholas C., Kandpal, Raj P., Athwal, Raghbir S.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913896/
https://ncbi.nlm.nih.gov/pubmed/19789346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1003
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