Inhibition or Deletion of Soluble Epoxide Hydrolase Prevents Hyperglycemia, Promotes Insulin Secretion, and Reduces Islet Apoptosis

Soluble epoxide hydrolase (sEH) is an enzyme involved in the metabolism of endogenous inflammatory and antiapoptotic mediators. However, the roles of sEH in diabetes and the pancreas are unknown. Our aims were to determine whether sEH is involved in the regulation of hyperglycemia in diabetic mice a...

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Detaylı Bibliyografya
Asıl Yazarlar: Luo, Pengcheng, Chang, Hsin-Hsin, Zhou, Yiqiang, Zhang, Shali, Hwang, Sung Hee, Morisseau, Christophe, Wang, Cong-Yi, Inscho, Edward W., Hammock, Bruce D., Wang, Mong-Heng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2010
Konular:
Endocrine and Diabetes
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913776/
https://ncbi.nlm.nih.gov/pubmed/20439437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.167544
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