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Codominant Expression of N-Acetylation and O-Acetylation Activities Catalyzed by N-Acetyltransferase 2 in Human Hepatocytes

Human populations exhibit genetic polymorphism in N-acetylation capacity, catalyzed by N-acetyltransferase 2 (NAT2). We investigated the relationship between NAT2 acetylator genotype and phenotype in cryopreserved human hepatocytes. NAT2 genotypes determined in 256 human samples were assigned as rap...

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Bibliografiske detaljer
Main Authors: Doll, Mark A., Zang, Yu, Moeller, Timothy, Hein, David W.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913773/
https://ncbi.nlm.nih.gov/pubmed/20430842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.168567
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