Estrogen Receptor β Signaling through Phosphatase and Tensin Homolog/Phosphoinositide 3-Kinase/Akt/Glycogen Synthase Kinase 3 Down-Regulates Blood-Brain Barrier Breast Cancer Resistance Protein

Breast cancer resistance protein (BCRP) is an ATP-driven efflux pump at the blood-brain barrier that limits central nervous system pharmacotherapy. Our previous studies showed rapid loss of BCRP transport activity in rat brain capillaries exposed to low concentrations of 17-β-estradiol (E2); this oc...

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Main Authors: Hartz, A. M. S., Madole, E. K., Miller, D. S., Bauer, B.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Neuropharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913769/
https://ncbi.nlm.nih.gov/pubmed/20460386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.168930
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