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Methadone: A Substrate and Mechanism-Based Inhibitor of CYP19 (Aromatase)
The peripheral conversion of testosterone to estradiol by aromatase is the primary source of endogenous estrogen in postmenopausal women. Studies indicating that placental aromatase is able to metabolize methadone to its primary metabolite, 2-ethylidene-1, 5-dimethyl-3, 3-diphenylpyrrolidin (EDDP),...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2913626/ https://ncbi.nlm.nih.gov/pubmed/20410453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.032474 |
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