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2-hydroxypropyl-β-cyclodextrin raises hearing threshold in normal cats and in cats with Niemann-Pick type C disease
2-hydroxypropyl-β-cyclodextrin (HPβCD) is a promising experimental therapy for Niemann-Pick type C disease that improved intracellular cholesterol transport, substantially reduced neurodegeneration and hepatic disease, and increased lifespan in npc1(−/−) mice. Based on the favorable treatment outcom...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2913583/ https://ncbi.nlm.nih.gov/pubmed/20357695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1203/PDR.0b013e3181df4623 |
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