Manipulation of Conformational Change in Proteins by Single-Residue Perturbations

Using the perturbation-response scanning (PRS) technique, we study a set of 25 proteins that display a variety of conformational motions upon ligand binding (e.g., shear, hinge, allosteric). In most cases, PRS determines single residues that may be manipulated to achieve the resulting conformational...

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Bibliografiske detaljer
Main Authors: Atilgan, C., Gerek, Z.N., Ozkan, S.B., Atilgan, A.R.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2010
Fag:
Protein
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913187/
https://ncbi.nlm.nih.gov/pubmed/20682272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.05.020
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