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Manipulation of Conformational Change in Proteins by Single-Residue Perturbations
Using the perturbation-response scanning (PRS) technique, we study a set of 25 proteins that display a variety of conformational motions upon ligand binding (e.g., shear, hinge, allosteric). In most cases, PRS determines single residues that may be manipulated to achieve the resulting conformational...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2913187/ https://ncbi.nlm.nih.gov/pubmed/20682272 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.05.020 |
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