Deferasirox is a powerful NF-κB inhibitor in myelodysplastic cells and in leukemia cell lines acting independently from cell iron deprivation by chelation and reactive oxygen species scavenging

BACKGROUND: Usefulness of iron chelation therapy in myelodysplastic patients is still under debate but many authors suggest its possible role in improving survival of low-risk myelodysplastic patients. Several reports have described an unexpected effect of iron chelators, such as an improvement in h...

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Autors principals: Messa, Emanuela, Carturan, Sonia, Maffè, Chiara, Pautasso, Marisa, Bracco, Enrico, Roetto, Antonella, Messa, Francesca, Arruga, Francesca, Defilippi, Ilaria, Rosso, Valentina, Zanone, Chiara, Rotolo, Antonia, Greco, Elisabetta, Pellegrino, Rosa M., Alberti, Daniele, Saglio, Giuseppe, Cilloni, Daniela
Format: Artigo
Idioma:Inglês
Publicat: Ferrata Storti Foundation 2010
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913079/
https://ncbi.nlm.nih.gov/pubmed/20534700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.016824
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