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Mechanism of human Hb switching: a possible role of the kit receptor/miR 221-222 complex
BACKGROUND: The human hemoglobin switch (HbF→HbA) takes place in the peri/post-natal period. In adult life, however, the residual HbF (<1%) may be partially reactivated by chemical inducers and/or cytokines such as the kit ligand (KL). MicroRNAs (miRs) play a pivotal role in normal hematopoiesis:...
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Main Authors: | , , , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Ferrata Storti Foundation
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2913072/ https://ncbi.nlm.nih.gov/pubmed/20305142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.018259 |
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