Targeted Gene Silencing Using RGD-Labeled Chitosan Nanoparticles

PURPOSE: To develop an Arg-Gly-Asp (RGD) peptide-labeled chitosan nanoparticle (RGD-CH-NP) as a novel tumor targeted delivery system for siRNA. EXPERIMENTAL DESIGN: RGD peptide conjugated with CH by thiolation reaction was confirmed by H-NMR. Binding of RGD-CH-NP with ανβ3 integrin was examined by f...

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Detalhes bibliográficos
Main Authors: Han, Hee Dong, Mangala, Lingegowda S., Lee, Jeong Won, Shahzad, Mian M.K., Kim, Hye Sun, Shen, Deyu, Nam, Eun Ji, Mora, Edna M., Stone, Rebecca L., Lu, Chunhua, Lee, Sun Joo, Roh, Ju Won, Nick, Alpa M., Lopez-Berestein, Gabriel, Sood, Anil K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912984/
https://ncbi.nlm.nih.gov/pubmed/20538762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-0005
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