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The Mdm2–p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor
Mdm2 has been well characterized as a negative regulator of the tumor suppressor p53. Recent studies have shown that Mdm2 is activated in response to a variety of oncogenic pathways independent of p53. Although its role as an oncogene via suppression of p53 function remains clear, growing evidence a...
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| Format: | Artigo |
| Jezik: | Inglês |
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Cold Spring Harbor Laboratory Press
2010
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2912554/ https://ncbi.nlm.nih.gov/pubmed/20679392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1941710 |
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