Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene.

BACKGROUND: Mdm-2, a zinc finger protein, negatively regulates the p53 tumor suppressor gene product by binding to it and preventing transcriptional activation (16). MATERIALS AND METHODS: Assays for p53 mediated transcription, repression and activation by mutant and wild-type p53 proteins were used...

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Bibliografiska uppgifter
Huvudupphovsmän: Chen, J., Lin, J., Levine, A. J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Feinstein Institute for Medical Research 1995
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2229942/
https://ncbi.nlm.nih.gov/pubmed/8529093
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