Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function

BACKGROUND: The key co-repressor complex components HDAC-2, Mi-2α/β and mSin3a are all critical to the regulation of gene transcription. HDAC-2 function is impaired by oxidative stress in a PI3Kδ dependant manner which may be involved in the chronic glucocorticoid insensitive inflammation in the lun...

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Main Authors: Marwick, John A, Stevenson, Christopher S, Chung, Kian Fan, Adcock, Ian M, Kirkham, Paul A
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2010
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912298/
https://ncbi.nlm.nih.gov/pubmed/20637110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-9255-7-33
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