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Synthesis and In Vitro Evaluation of Potential Sustained Release Prodrugs via Targeting ASBT
The objective was to synthesize prodrugs of niacin and ketoprofen that target the human apical sodium-dependent bile acid transporter (ASBT) and potentially allow for prolonged drug release. Each drug was conjugated to the naturally occurring bile acid chenodeoxycholic acid (CDCA) using lysine as a...
में बचाया:
| मुख्य लेखकों: | , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2010
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2912288/ https://ncbi.nlm.nih.gov/pubmed/20600720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2010.06.039 |
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