Putative contribution of CD56 positive cells in cetuximab treatment efficacy in first-line metastatic colorectal cancer patients

BACKGROUND: Activity of cetuximab, a chimeric monoclonal antibody targeting the epidermal growth factor receptor, is largely attributed to its direct antiproliferative and proapoptotic effects. Antibody-dependent cell-mediated cytotoxicity (ADCC) could be another possible mechanism of cetuximab anti...

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Main Authors: Maréchal, Raphaël, De Schutter, Jef, Nagy, Nathalie, Demetter, Pieter, Lemmers, Arnaud, Devière, Jacques, Salmon, Isabelle, Tejpar, Sabine, Van Laethem, Jean-Luc
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912265/
https://ncbi.nlm.nih.gov/pubmed/20591136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-340
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