MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

Mechanistic target of rapamycin (MTOR) plays a critical role in the regulation of cell growth and in the response to energy state changes. Drugs inhibiting MTOR are increasingly used in antineoplastic therapies. Myocardial MTOR activity changes during hypertrophy and heart failure (HF). However, whe...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Zhang, Denghong, Contu, Riccardo, Latronico, Michael V.G., Zhang, Jian Ling, Rizzi, Roberto, Catalucci, Daniele, Miyamoto, Shigeki, Huang, Katherine, Ceci, Marcello, Gu, Yusu, Dalton, Nancy D., Peterson, Kirk L., Guan, Kun-Liang, Brown, Joan Heller, Chen, Ju, Sonenberg, Nahum, Condorelli, Gianluigi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2010
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912201/
https://ncbi.nlm.nih.gov/pubmed/20644257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43008
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia