Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus

Febrile seizures are a common childhood seizure disorder and a defining feature of genetic epilepsy with febrile seizures plus (GEFS+), a syndrome frequently associated with Na(+) channel mutations. Here, we describe the creation of a knockin mouse heterozygous for the C121W mutation of the β1 Na(+)...

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Hauptverfasser: Wimmer, Verena C., Reid, Christopher A., Mitchell, Suzanne, Richards, Kay L., Scaf, Byron B., Leaw, Bryan T., Hill, Elisa L., Royeck, Michel, Horstmann, Marie-Therese, Cromer, Brett A., Davies, Philip J., Xu, Ruwei, Lerche, Holger, Berkovic, Samuel F., Beck, Heinz, Petrou, Steven
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2010
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912193/
https://ncbi.nlm.nih.gov/pubmed/20628201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42219
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