The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse β cells

Insufficient insulin secretion and reduced pancreatic β cell mass are hallmarks of type 2 diabetes (T2DM). Here, we confirm that a previously identified polymorphism (rs2295490/Q84R) in exon 2 of the pseudokinase-encoding gene tribbles 3 (TRB3) is associated with an increased risk for T2DM in 2 popu...

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Detalhes bibliográficos
Main Authors: Liew, Chong Wee, Bochenski, Jacek, Kawamori, Dan, Hu, Jiang, Leech, Colin A., Wanic, Krzysztof, Malecki, Maciej, Warram, James H., Qi, Ling, Krolewski, Andrzej S., Kulkarni, Rohit N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912176/
https://ncbi.nlm.nih.gov/pubmed/20592469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36849
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