Physiological tonicity improves human chondrogenic marker expression through nuclear factor of activated T-cells 5 in vitro

INTRODUCTION: Chondrocytes experience a hypertonic environment compared with plasma (280 mOsm) due to the high fixed negative charge density of cartilage. Standard isolation of chondrocytes removes their hypertonic matrix, exposing them to nonphysiological conditions. During in vitro expansion, chon...

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Detalhes bibliográficos
Main Authors: van der Windt, Anna E, Haak, Esther, Das, Ruud HJ, Kops, Nicole, Welting, Tim JM, Caron, Marjolein MJ, van Til, Niek P, Verhaar, Jan AN, Weinans, Harrie, Jahr, Holger
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911888/
https://ncbi.nlm.nih.gov/pubmed/20492652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3031
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