Inhibitory effects of ZSTK474, a novel phosphoinositide 3-kinase inhibitor, on osteoclasts and collagen-induced arthritis in mice

INTRODUCTION: Targeting joint destruction induced by osteoclasts (OCs) is critical for management of patients with rheumatoid arthritis (RA). Since phosphoinositide 3-kinase (PI3-K) plays a critical role in osteoclastogenesis and bone resorption, we examined the effects of ZSTK474, a novel phosphoin...

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Detalhes bibliográficos
Main Authors: Toyama, Shoko, Tamura, Naoto, Haruta, Kazuhiko, Karakida, Takeo, Mori, Shigeyuki, Watanabe, Tetsuo, Yamori, Takao, Takasaki, Yoshinari
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911876/
https://ncbi.nlm.nih.gov/pubmed/20482767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3019
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