Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity

INTRODUCTION: Angiopoietin-2 (ang-2), an angiogenic peptide released by endothelial cell Weibel-Palade bodies (WPBs), increases endothelial activation and vascular permeability. Ang-2 is raised in severe sepsis but the mechanisms underlying this are not known. Nitric oxide (NO) inhibits WPB exocytos...

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Detalhes bibliográficos
Main Authors: Davis, Joshua S, Yeo, Tsin W, Piera, Kim A, Woodberry, Tonia, Celermajer, David S, Stephens, Dianne P, Anstey, Nicholas M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911723/
https://ncbi.nlm.nih.gov/pubmed/20482750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc9020
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