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Dichloroacetate- and Trichloroacetate-Induced Oxidative Stress in The Hepatic Tissues of Mice after Long Term Exposure

Dichoroacetate (DCA) and trichloroacetate (TCA) were found to be hepatotoxic and hepatocarcinogenic in rodents. To investigate the role of oxidative stress in the long term hepatotoxicity of the compounds, groups of mice were administered 7.7, 77, 154 and 410 mg/kg/day, of either DCA or TCA, by gava...

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Main Authors: Hassoun, Ezdihar A., Cearfoss, Jacquelyn, Spildener, Jessica
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911518/
https://ncbi.nlm.nih.gov/pubmed/20222146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jat.1516
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